Among the many anti-free radical natural products, silymarin is one of the few drugs that should be widely used clinically. After nearly 30 years of clinical testing, the drug's exact efficacy and extremely low toxicity have been demonstrated.
Silymarin is present in bitter thistle and is a general term for various flavonoids in bitter thistle. Milk thistle has three main components, Silybin. Silydianin and Silychristin. Silymarin has been included in the FDA as a nutraceutical and therapeutic agent for hepatotoxicity. Silymarin has anti-oxidant, anti-inflammatory and anti-fibrotic properties and can be used for different liver diseases, especially chronic liver disease, cirrhosis, and hepatocellular carcinoma. In fact, the antioxidant and anti-inflammatory effects of silymarin are reduced viral-associated liver damage by inflammatory cascade softening and immune system regulation. It can also exert a direct antiviral effect on hepatitis C by intravenous administration.
For patients with alcohol-abusing liver disease, silymarin can increase their cell viability and reduce lipid peroxidation and cell necrosis. In addition, silymarin (Silibinin) also has important biological effects on nonalcoholic fatty liver. These substances can antagonize the progression of nonalcoholic fatty liver disease by interfering with various therapeutic targets: oxidative stress, insulin resistance, liver fat accumulation, and mitochondrial dysfunction. Silymarin can also be used in cirrhosis and hepatocellular carcinoma, which presents a common end stage of different liver diseases by regulating different molecular patterns. This study investigated the effects of silymarin (silymarin) on chronic liver disease, cirrhosis, and hepatocellular carcinoma.
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