Nicotinamide ribose (abbreviated as NR) is an important coenzyme precursor, also known as vitamin B3. This coenzyme is nicotinamide adenine dinucleotide (NAD+, also known as coenzyme I), a coenzyme that transfers protons (more precisely, hydrogen ions), which occurs in many metabolic reactions in cells. Nad+ is involved in the decomposition of the compound such as proteins, carbohydrates, and fats. As the cell ages or becomes diseased, NAD+ number decreases. Therefore, supplementing nicotinamide ribose can increase the content of this coenzyme (NAD+) and increase the basic metabolic activity of the cells, thereby significantly improving cell viability and improving various physiological functions of the human body.
Nicotinamide ribose was first documented by humans in 1944 when it was known as the growth factor of Haemophilus influenza, also known as growth factor V. Haemophilus influenza is a bacterium that lives in the blood and lives on blood. Growth factor V purified from blood has three structures: NAD+ (nicotinamide adenine dinucleotide), NMN (nicotinamide mononuclear acid) and NR (nicotinamide ribose). It was later discovered that only nicotinamide ribose (NR) can rapidly promote the growth of this bacterium, whereas niacin, previously thought to be NAD+ precursors (nicotinamide, tryptophan and aspartic acid) did not have this effect.
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